2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-103701AR
    L-Ascorbic acid 2-phosphate magnesium (Standard) 113170-55-1
    L-Ascorbic acid 2-phosphate (magnesium) (Standard) is the analytical standard of L-Ascorbic acid 2-phosphate (magnesium). This product is intended for research and analytical applications. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) is a?long-acting?vitamin?C?derivative?that can stimulate collagen formation and expression. L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation.
    L-Ascorbic acid 2-phosphate magnesium (Standard)
  • HY-104026S5
    L-Kynurenine-13C10 sulfate hydrate
    L-Kynurenine-13C10 sulfate hydrate is the C13 labeled L-Kynurenine sulfate hydrate. L-Kynurenine is an aryl hydrocarbon receptor agonist.
    L-Kynurenine-13C10 sulfate hydrate
  • HY-106019CR
    Liarozole dihydrochloride (Standard) 1883548-96-6
    Liarozole (dihydrochloride) (Standard) is the analytical standard of Liarozole (dihydrochloride). This product is intended for research and analytical applications. Liarozole (R75251) dihydrochloride is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole dihydrochloride inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of RA (IC50=7 μM), resulting in increased tissue levels of RA. Liarozole dihydrochloride shows antitumoral properties.
    Liarozole dihydrochloride (Standard)
  • HY-106577AS
    (-)-(S)-Cibenzoline-d4
    (-)-(S)-Cibenzoline-d4 (Escibenzoline-d4) is deuterium labeled (-)-(S)-Cibenzoline. (-)-(S)-Cibenzoline (Escibenzoline), a S(+)-enantiomer of Cibenzoline, is an antiarrhythmic agent.
    (-)-(S)-Cibenzoline-d4
  • HY-106577S1
    Cibenzoline-d5
    Cibenzoline-d5 (Cifenline-d5) is deuterium labeled Cibenzoline. Cibenzoline is a class Ia antiarrhythmic active molecule with low anticholinergic activity. Cibenzoline is a KATP channel inhibitor, acting through the pore forming subunit Kir6.2, with an IC50 of 22.2 μM. Cibenzoline inhibits IKr and IKs currents with IC50 values of 8.8 μM and 12.3 μM, respectively. Cibenzoline is used in the study of cardiac diseases. In addition, Cibenzoline can induce hypoglycemia.
    Cibenzoline-d5
  • HY-113016S1
    Elaidic acid-d17
    Elaidic acid-d17 is deuterium labeled Elaidic acid. Elaidic acid is the major trans fat found in hydrogenated vegetable oils and can be used as a pharmaceutical solvent.
    Elaidic acid-d17
  • HY-113046S1
    5-Methyltetrahydrofolic acid-13C6 212248-92-5
    5-Methyltetrahydrofolic acid-13C6 (5-Methyl THF-13C6) is 13C labeled 5-Methyltetrahydrofolic acid. 5-Methyltetrahydrofolic acid (5-Methyl THF) is the main circulating form of folic acid in the body and is involved in a variety of biochemical reactions. 5-Methyltetrahydrofolic acid regulates cardiovascular function by increasing the production of endothelin-1 (ET-1) in low-density lipoprotein-treated endothelial cells and can be used in the study of cardiovascular diseases.
    5-Methyltetrahydrofolic acid-13C6
  • HY-113071AR
    Mevalonic acid (lithium salt) (Standard) 2618458-93-6
    Mevalonic acid (lithium salt) (Standard) is the analytical standard of Mevalonic acid (lithium salt). This product is intended for research and analytical applications. Mevalonic acid (MVA) lithium salt is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid lithium salt is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid lithium salt can be used in studies of myopathy and heart failure.
    Mevalonic acid (lithium salt) (Standard)
  • HY-113097S1
    3α,7α-Dihydroxycoprostanic acid-d5
    3α,7α-Dihydroxycoprostanic acid-d5 is deuterium labeled 3α,7α-Dihydroxycoprostanic acid. 3α,7α-Dihydroxycoprostanic acid is an endogenous metabolite. 3α,7α-Dihydroxycoprostanic acid, a bile acid, is the precursor to chenodeoxycholic acid.
    3α,7α-Dihydroxycoprostanic acid-d5
  • HY-113147S1
    L-Palmitoylcarnitine-d9 2847775-90-8
    L-Palmitoylcarnitine-d9 is deuterium labeled L-Palmitoylcarnitine. L-Palmitoylcarnitine, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2.
    L-Palmitoylcarnitine-d9
  • HY-113202S1
    Stearoyl-L-carnitine-d9 chloride 2936622-19-2
    Stearoyl-L-carnitine-d9 chloride is the deuterium labeled Stearoyl-L-carnitine chloride. Stearoyl-L-carnitine chloride, a fatty ester lipid molecule, is an endogenous metabolite. Stearoyl-L-carnitine chloride can be used as PKC inhibitor. Stearoyl-L-carnitine chloride accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoyl-L-carnitine chloride inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoyl-L-carnitine chloride acts as a metabolomics biomarker for Parkinson’s disease. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2.
    Stearoyl-L-carnitine-d9 chloride
  • HY-113295S3
    Salicyluric acid-d4
    Salicyluric acid-d4 is deuterated labeled Salicyluric acid (HY-113295). Salicyluric acid is an endogenous metabolite.
    Salicyluric acid-d4
  • HY-113432S1
    Nudifloramide-d6 2012598-72-8
    Nudifloramide-d6 (2PY-d6) is deuterium-labeled Nudifloramide (HY-113432).
    Nudifloramide-d6
  • HY-121467S1
    Acotiamide-d4
    Acotiamide-d4 (Z-338 (free base)-d4) is deuterium labeled Acotiamide. Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.
    Acotiamide-d4
  • HY-125138S1
    ω-Muricholic acid-d4
    ω-Muricholic acid-d4 (ω-MCA-d4) is deuterium labeled ω-Muricholic Acid. ω-Muricholic acid (ω-MCA) is a murine-specific secondary bile acid.
    ω-Muricholic acid-d4
  • HY-126042S4
    (±)-Lisofylline-d4 1185879-05-3
    (±)-Lisofylline-d4 ((±)-Lisophylline-d4) is deuterium labeled (±)-Lisofylline. (±)-Lisofylline ((±)-Lisophylline) is the racemate of Lisofylline. Lisofylline inhibits the generation of phosphatidic acid and free fatty acids. Lisofylline also blocks the release of pro-inflammatory cytokines in oxidative tissue injury, in response to cancer chemotherapy and in experimental sepsis. Lisofylline can be used for Type 1 diabetes research.
    (±)-Lisofylline-d4
  • HY-128393S1
    Trilinolein-13C54
    Trilinolein-13C54 is the 13C-labeled Trilinolein (HY-128393). Radioactive isotopes labeled compounds can be used in metabolic analysis, allowing the movement of individual atoms to be precisely tracked and quantified.
    Trilinolein-13C54
  • HY-141580S1
    C18 Dihydroceramide-d3-1 2699606-99-8
    C18 Dihydroceramide-d3-1 (N-octadecaoyl-D-eytho-Dihydosphigosie-d3) is deuterium labeled C18 Dihydroceramide. C18 Dihydroceramide is an ester product.
    C18 Dihydroceramide-d3-1
  • HY-143712S1
    Allolithocholic Acid-d4
    Allolithocholic Acid-d4 (3α-hydoxy-5α-Cholaoic Acid-d4, allo-LCA-d4) is deuterium labeled Allolithocholic acid. Allolithocholic acid is a steroid acid could found in normal serum and feces. Allolithocholic acid facilitates excretion, absorption, and transport of fats and sterols in the intestine and liver.
    Allolithocholic Acid-d4
  • HY-144856S1
    Sapropterin-d3 2747956-15-4
    Sapropterin-d3 ((6R)-BH4-d3) is deuterium labeled Sapropterin. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU).
    Sapropterin-d3
Cat. No. Product Name / Synonyms Application Reactivity